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Brain scan predicts dementia risk by reading brain’s ‘hidden ageing clock’

A new type of MRI scan detects how quickly someone is ageing and how likely they are to develop dementia long before symptoms might surface

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Scientists examine brain scan images in a laboratory. A new MRI tool called DunedinPACNI has been unveiled that can predict dementia risk and ageing through brain scans. Photo: Shutterstock
This is the 68th instalment in a series on dementia, including the research into its causes and treatment, advice for carers, and stories of hope.

A team of scientists from Duke University and Harvard University in the US, and the University of Otago in New Zealand, has just unveiled a new MRI-based tool that reads the brain’s “hidden ageing clock”.

The DunedinPACNI takes the front of its name from the Dunedin Study, a long-running health research project in New Zealand that began in 1972, while PACNI stands for Pace of Ageing Calculated from NeuroImaging.

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It has been tracking 1,037 babies born in Dunedin from birth, continuing through their entire lives. Think of it as a 50-year time-lapse study on human health; it is often called “the world’s most detailed study of human development”.

The DunedinPACNI uses an MRI-based tool like this MRI machine to read the brain’s “hidden ageing clock”. Photo: Shutterstock
The DunedinPACNI uses an MRI-based tool like this MRI machine to read the brain’s “hidden ageing clock”. Photo: Shutterstock

The Dunedin Study’s value comes from the fact that it follows the same people over time. Researchers regularly collect detailed data on all aspects of their health – physical, mental and brain health, lifestyle, relationships, and even genetics.

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