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Anthea Rowan

This is the 38th instalment in a series on dementia, including the research into its causes and treatment, advice for carers, and stories of hope.
A regular refrain from my mother was, “I wish I’d become a teacher”.
She would have made a very good teacher: she taught us at home when we were little. She taught a French-speaking friend’s daughter to speak English. She taught me how to teach my children to read and write.
She had exactly the right approach: she was patient, curious, made learning fun, and was a voracious reader.
I wonder now if having an occupation might have protected her from depression – she often articulated the loss she felt when her children went away to school as a key reason for her low moods.
I also wonder if having a job might have protected her from the dementia that took her life. The science says it might have done.

Dr Trine Holt Edwin, a geriatrician and postdoctoral fellow at the Oslo Clinical Dementia Research group at Oslo University Hospital, in Norway, recently authored a study that examined the connection between cognitive impairment and dementia in later life and occupation in midlife.
Holt Edwin’s findings – which examined people between the ages of 30 and 65 – found that the most cognitively challenging jobs help to build cognitive reserve.
A bigger or better cognitive reserve increases the brain’s resilience and flexibility, and allows for cognitive performance that is better than expected later in life, given the degree of life-course-related brain changes or disease.
The cognitive reserve hypothesis, she says, presupposes that “cognitive abilities acquired through education and other cognitively stimulating activities throughout the lifespan can delay the onset of mild cognitive impairment and dementia”.
Holt Edwin’s study, of more than 7,000 Norwegians across 305 different occupations, found that those who held the least mentally challenging – or menial – jobs had a 66 per cent greater risk of mild cognitive impairment, and a 31 per cent greater risk of dementia, after the age of 70 compared with those in more mentally demanding positions.

It illustrates how important work is, Holt Edwin said: using your brain and learning new things as you get older strengthens your cognitive reserve. It may even partially counteract the effect of the APOE4 allele – a gene known to be linked to Alzheimer’s development.
The phrase “cognitive reserve” was coined by Professor Yaakov Stern, a neuropsychologist and chief of the Cognitive Neuroscience Division in the Department of Neurology at Columbia University in the US state of New York.
Stern published a paper in the early 1990s that observed people with higher education were less likely to develop Alzheimer’s disease. When he presented it at the Academy of Neurology, friends and colleagues made fun of the idea.
“It seemed so far-fetched,” he remembers, “that something like education could counter the plaques and tangles of Alzheimer’s”.
He used “cognitive reserve” to differentiate it from the “brain reserve” described by Robert Katzman a few years previously.

Katzman published research in the late 1980s based on the examination of the brains of elderly residents of a care home.
He found a number of their brains showed significant pathology of Alzheimer’s, yet their cognition ranked in the top 20 per cent of the nursing home residents – as good as, or better, than residents without any signs of Alzheimer’s in their brain.
Katzman concluded that this was because these people had bigger, heavier brains with more neurons and synapses, so they had more brain to lose in the face of dementia.
Katzman was a pioneer in the field of Alzheimer’s; his work demonstrated how widespread the illness actually was. When he published research on the prevalence of the illness in China, he concluded that people with higher levels of education appeared to have a lower incidence of dementia.
When he read this, Stern assumed the findings were flawed.
“They were using a mental status exam and I felt sure – of course – that people with higher education would do better on that test,” he said. “I felt it needed an incidence study – starting with people who were not demented and following them over time.”

Stern and his team set out to do exactly that and found that people with fewer than eight years of education had twice the risk of developing dementia compared to those with more.
They also found that people with “low lifetime occupational attainment” bore a similar risk. The implication of these findings, Stern concluded, was that educational and occupational experiences imparted a reserve against the expression of Alzheimer’s pathology.
Holt Edwin’s results support this hypothesis “by showing that cognitive abilities acquired through both education and occupation during early [life] and midlife appear to offer resilience against cognitive decline”.
Categorising individuals according to the level of an occupation’s complexity versus how routine-oriented their work was, the scientists found the jobs with the “most mentally stimulating trajectory” were the ones that seemed to offer greatest protection.
More mundane work – that of cleaners, mail carriers and road workers – was among the least mentally challenging.

Researcher Pamela Almeida-Meza, at University College London, found that even those who were not afforded the same educational or employment advantage can make up for the losses in learning, by reading for example.
She refers to the 1946 British National Birth Cohort study – a study arranged by social class and initially consisting of 5,362 people chosen at random from all births in England, Scotland, and Wales during a single week in March 1946 – as evidence of this.
At the time, she says, there were few women in higher education or senior positions at work, but many were self-educating, which had a positive impact ultimately on brain health.
If we were to extrapolate our results, Holt Edwin adds, “You could say that our study shows that it is never too late, or a waste of time, to start learning something new”.
All cognitively demanding activities later in life contribute to strengthening one’s cognitive reserve, she says, even if you are not working and did not work in an especially cerebral or taxing position.
Ironically, given my mother’s voiced wish that she had been a teacher, the jobs ranked as most stimulating were teachers and university lecturers.
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Wellness

How having a mentally stimulating job in midlife may protect against dementia later on

Having a mentally stimulating job, such as being a teacher (above), in midlife may help build cognitive reserve which protects you against dementia as you age. Photo: Shutterstock

Dr Trine Holt Edwin, of Oslo University Hospital, in Norway. Photo: Anne Elisabeth Næss (Norwegian Health Association)

Yaakov Stern, an American cognitive neuroscientist and professor of neuropsychology at Columbia University in New York state, coined the term “cognitive reserve”. Photo: Columbia University

New research suggests that it is never too late, or a waste of time, to start learning something new. Photo: Shutterstock

Jobs ranked as most mentally stimulating – and therefore able to build up greater cognitive reserve – included teachers and university professors. Photo: Shutterstock

Pamela Almeida Meza, a researcher at University College London. Photo: www.researchgate.net/profile/Pamela-Almeida-Meza

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Lifestyle

Health & Wellness

Health

Decoding dementia

How caring for a parent with dementia taught me about symptoms, prevention and why seeking out the latest research is so important

Author Anthea Rowan (right) with her mother.

Author Anthea Rowan (right) with her mother, who has Alzheimer’s disease, the most common type of dementia. Photo: Anthea Rowan

Anthea with her mother. Photo: Anthea Rowan

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Staying active can help prevent or delay the onset of dementia, studies suggest. Photo: Shutterstock

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Timothy Rittman, the neurologist who led the dementia research at Cambridge University. Photo: Cambridge University

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Having blood pressure that is too high or too low has been linked to a higher risk of dementia, but it’s never too late to start living a healthy lifestyle that will help maintain optimal blood pressure. Photo: Shutterstock


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Dr Ruth Peters was lead author of a study looking at the links between blood pressure and dementia. Photo: Dr Ruth Peters

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The cover of Marc Milstein’s book. Photo: Marc Milstein

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‘Like a light switch’: how sundowning syndrome affects dementia sufferers – and their carers; what it is and tips for how to cope

A person with dementia may experience “sundowning” syndrome - towards the end of the day they become more agitated, confused, panicked, resistant to instruction and restless. This affects their carers, too. Photo: Shutterstock

A person in bed, unable to sleep. Conservative estimates suggest about 20 per cent of dementia patients experience sundowning at some point.

Trey Todd is a neuroscientist at the University of Wyoming. Photo: Trey Todd

Sundowning was coined in 1987 by Lois Evans of Penn Nursing at Pennsylvania University. Photo: University of Pennsylvania

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Taking a patient with sundowning syndrome for a walk at a consistent time each day, morning or evening, may alleviate symptoms. Photo: Shutterstock

Getting out into the daylight early in the day is good for our sleep patterns, whether we have dementia or not. Photo: Shutterstock

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Anthea Rowan and her husband on their wedding day. Photo: courtesy of Anthea Rowan

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Residents relax around the fountain in the theatre square at The Hogeweyk. Photo: The Hogeweyk 

Residents of The Hogeweyk respond positively to their increased autonomy. Photo: The Hogeweyk

Residents at the healthcare facility take part in a painting class. Photo: The Hogeweyk

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Hearing loss has been linked to a higher risk of dementia and cognitive decline,  say experts, who recommend testing for preventable hearing problems (above).  Photo: Getty Images

Alison Huang, a senior research associate at the Cochlear Centre at Johns Hopkins, in the US, says hearing loss makes the brain work harder to process sounds. Photo: Johns Hopkins

Jiang Fan from the School of Public Health at China’s Shandong University. Photo: Shandong University

Checking your hearing in midlife is crucial, and can help you stave off cognitive deterioration. Photo: Shutterstock

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HRT (hormone replacement therapy) use has been linked to better cognition, blood flow and brain size and a reduction in dementia and other neurodegenerative disease in recent studies. Photo: Shutterstock

If HRT is started after the age of 65, brain cells will have already been deprived of oestrogen for many years. This could mean there is a decline in neuronal connections – the brain’s messaging system. Photo: Shutterstock

HRT was found to be most effective when introduced early in menopause, says Anne Marie Minihane, director of the UK’s Norwich Institute of Healthy Ageing at the University of East Anglia. Photo: University of East Anglia

Dr Andrea Kwakowsky from at the University of Galway in Ireland believes the “critical period” for starting HRT is within five years of menopause. Photo: University of Galway

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Dr Susan Mitchell is head of policy at Alzheimer’s Research UK. Photo: Dr Susan Mitchell

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Professor Roger Wong of the department of public health and preventive medicine at the State University of New York’s Upstate Medical University. Photo: Roger Wong

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The writer, Anthea Rowan, with her mother. Photo: Anthea Rowan

Taking medications that block the action of acetylcholine can lead to memory loss, problems with spatial awareness, and cognitive decline. Photo: Shutterstock

Studies have found that anticholinergic drugs carried “significant’ dementia risk” for the over-65s. Photo: Shutterstock

Doctors need to be mindful of the risks posed by anticholinergic drugs, especially to an already at-risk population: the over 65s. Photo: Shutterstock

How to safeguard your ageing brain: build ‘cognitive reserve’ with mental and physical exercise, and stay active and socially engaged

The phrase ‘use it or lose it’ is not just a hypothesis, it’s a basic biological fact that holds as true for our brains as our muscles or bones. Photo:
Shutterstock

Our brains, like our muscles need regular use to stay healthy and flexible, say experts, and keeping our brains active builds our ‘cognitive reserve’, helping us to stave off dementia. Photo: Shutterstock

Geriatric psychiatrist Dr David Merrill recommends the active pursuit of activities that keep the brain sharp to stave off dementia. Photo: Dr David Merrill

Dorina Cadar says cultural and social engagement, reading, doing crossword puzzles, visiting art galleries, clubs and cinemas, and volunteering all increase our cognitive reserve. Photo: Dorina Cadar

Visiting an art gallery or doing something new and different are good ways to build up cognitive reserve. Photo: Shutterstock 

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Yoga has health benefits including better brain neuroplasticity, improved sleep quality, and more robust cardiorespiratory fitness, all of which help people experiencing cognitive decline or dementia. Photo: Shutterstock

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Yoga could be helpful in managing brain inflammation, particularly with its mindfulness component. Photo: Shutterstock

Wendy Du is the founder of Shan Studios in Hong Kong. Photo: Wendy Du/Shan Studios

Du has maintained a daily yoga practice for 10 years. Photo: Courtesy of Shan Studios

5 nutrients good for brain health that can delay dementia, or prevent it, and foods to eat with a high concentration of them

Research has identified some key nutrients we need in our diets to maintain good cognitive function and delay or prevent the onset of dementia. Photo: Shutterstock

Eating healthy isn’t just good for our bodies, it’s good for our brains, too. Photo: Shutterstock

How having a mentally stimulating job in midlife may protect against dementia later on

Author’s mother wished she had been a teacher; science shows it might have helped protect her against the dementia that took her life