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Chinese scientists caught neurons ‘kissing’ each other with cutting-edge tech

Millisecond ‘kiss and run’ exchange – captured in a lab in China on the world’s first camera equipped to do it – solves a 50-year-old debate

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An illustration of the kiss-shrink-run mechanism of synaptic vesicle release. Photo: Handout
Dannie Pengin Beijing

Chinese scientists have captured the “kiss-shrink-run” process of neuronal communication using the world’s first camera with nanometre resolution and a millisecond-scale imaging speed.

This cutting-edge cryogenic electron microscopy development enables the team to freeze moments of neurotransmission in time and clearly observe the complete dynamic process of the synaptic vesicle – a tiny, membrane-bound sac in a neuron that stores neurotransmitters.

Their findings have also helped to resolve a key scientific debate that has plagued neuroscientists for half a century.

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This achievement – led mainly by biologists from the University of Science and Technology of China (USTC) and the Shenzhen Institutes of Advanced Technology, an affiliate of the Chinese Academy of Sciences – was published by the academic journal Science on Thursday.

The way our brain works relies on the efficient and precise transmission of signals between the hundreds of billions of neurons. These signals are carried by tiny structures called synaptic vesicles.

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Yet for decades, the field of neuroscience has been perplexed by an unsolved mystery: how do synaptic vesicles achieve release?

This has long remained elusive primarily because the process occurs on a timescale of milliseconds, while structural changes take place on a nanoscale, making it difficult for traditional techniques to capture its transient dynamics.

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