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Chinese mRNA booster fights Omicron 4 times better than inactivated Covid-19 vaccines, researchers say

  • AWcorna vaccine produced 4.4 times more Omicron antibodies than Sinovac booster, scientists behind clinical trial write in Cell Research journal
  • Home-grown mRNA jab could be China’s best bet against the highly transmissible variant, with Pfizer-BioNTech’s version yet to clear regulatory hurdle

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AWcorna, China’s first mRNA vaccine, has been developed by  Abogen Biosciences, Walvax Biotechnology, and the Academy of Military Medical Sciences. Photo:  AP
China’s home-grown mRNA Covid-19 vaccine produces stronger antibodies against the Omicron variant than inactivated shots when given as a booster, a study has shown.
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The AWcorna vaccine is the latest in a string of Chinese shots seeking to improve public immunity against the highly transmissible strain of the Sars-Cov-2 coronavirus that causes Covid-19, in a country where most residents were inoculated with inactivated doses.

Nearly 90 per cent of China’s population have been fully vaccinated and about 59 per cent have received a booster. But only about 4.8 per cent of the boosted population received a vaccine using a different technology.

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Third Chinese Covid-19 vaccine gets emergency-use approval from WHO

Third Chinese Covid-19 vaccine gets emergency-use approval from WHO

“The effectiveness of AWcorna in preventing infection by Sars-CoV-2 and other variants of concern remains to be determined,” researchers behind the study wrote in peer-reviewed journal Cell Research earlier this week.

“[However] the induction of potent neutralising antibodies against wild type [original strain coronavirus] and variants of concern, as well as the affordable safety profile, support the emergency use of AWcorna as a heterologous booster in China.”

The AWcorna vaccine, formerly known as ARCoV and co-developed by Walvax Biotechnology, Suzhou Abogen Biosciences Co and the Academy of Military Medical Sciences, appears to be China’s best chance at getting a home-grown mRNA vaccine in a market dominated by inactivated vaccines.
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It has been in the final stage of clinical trials for months, while the globally distributed Pfizer-BioNTech mRNA vaccine remains stuck in the approval process for import by Chinese partner Shanghai Fosun Pharmaceutical Co (Fosun Pharma).
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