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Ozempic workouts build muscle that weight-loss drugs shrink. But are they anything new?

Workouts at gyms to combat muscle loss caused by GLP-1 drugs are gaining traction, but do they differ from regular strength training?

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Trainers are targeting patients on GLP-1 weight-loss drugs. Some say the workouts are just regular resistance training repackaged. Photo: Shutterstock

It is 10am on a Friday at Surfcore Fitness, a boutique gym in Los Angeles, and a 52-year-old woman is following an exercise circuit as her trainer watches on.

The fashion consultant, who is squeezing in a session before work, lifts relatively light weights while doing simple movements to build strength: goblet squats with a 3kg (6lb) kettlebell, then bicep curls with a 5kg weight.

You would never guess it, but this is the latest exercise craze in action: the Ozempic workout.

GLP-1 drugs such as Wegovy, Ozempic, Zepbound and Mounjaro have helped millions of people combat type 2 diabetes and cardiovascular disease as well as shed weight.
GLP-1 drugs such as Wegovy, Ozempic, Zepbound and Mounjaro have helped millions of people with type 2 diabetes and obesity, but they can also reduce muscle, making people weaker. Photo: Instagram/glp1training
GLP-1 drugs such as Wegovy, Ozempic, Zepbound and Mounjaro have helped millions of people with type 2 diabetes and obesity, but they can also reduce muscle, making people weaker. Photo: Instagram/glp1training

The class of drugs – GLP-1 receptor agonists – has been around for two decades as a diabetes medication. The drugs’ popularity as a tool for weight loss skyrocketed after the United States Food and Drug Administration (FDA) approved Wegovy for weight management in 2021.

But these drugs have also created new challenges. The weight loss they spur often comes with a reduction in lean body mass that includes muscle, making people physically weaker.

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